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Their literature search identified 22 relevant studies (12 clinical trials, including seven randomized controlled trials [RCTs], and 10 observational investigations)

Long-term safety data of above materials in vivo remains further study

Though many of these strategies remain experimental, their convergence with real-world data, digital phenotyping, and precision medicine frameworks heralds a transformative decade ahead

In both pathways, cysteine-dependent proteases known as caspases execute apoptotic cell death by cleaving key structural and regulatory proteins, primarily through the action of caspase-3 (CASP3) and caspase-7 (CASP7), with caspase-6 (CASP6) contributing to downstream substrate cleavage and apoptotic progression