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J Pharm Sci 78:165171 Hevener AL, Olefsky JM, Reichart D, Nguyen MA, Bandyopadyhay G, Leung H-Y, Watt MJ, Benner C, Febbraio MA, Nguyen A-K (2007) Macrophage PPAR is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

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Due to their potent antioxidant capabilities, scientists, pharmacologists, and clinicians have been studied these bioactive compounds extensively

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The effect was abolished by a PI3K inhibitor placing the mechanism on PI3K/AKT

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