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In addition, there was a clinically relevant improvement in cognitive performance in at least three out of 15 individuals

Oral Contraceptives Types of birth control known to deplete Vitamin C 1 Estradiol, Estradiol combinations, Ethinyl Estradiol, Ethinyl Estradiol combinations, Levonorgestrel, Norethindrone Some research suggests that oral contraceptives containing estrogen increase Vitamin C metabolism, thus decreasing the levels of Vitamin C in platelets and some white blood cells

In an 8-week open-label trial, a group of researchers evaluated the effect of Clostridium butyricum MIYAIRI 588 (CBM588) in patients with treatment-resistant MMD in an open-label study (Miyaoka et al., 2018)