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Overexpression of miR-146a and miR-200b downregulates NR2A and NR2B proteins, contributing to cognitive deficits [71], while miR-137 controls excitatory synapse maturation and plasticity by regulating GluA1 expression, with its levels modulated by mGluR5 activation [63]

Rats were group housed (23 rats per cage) at standard conditions (temperature: +24 2 C

Briefly, 100 l of fresh mitochondria extracted from liver tissues were mixed with 900 l staining working solution and then the fluorescence intensity was assessed using a fluorescence microplate reader (BioTek, Winooski, VT, USA)

Research shows it may influence nitric oxide signaling and cytokine activity