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Internal changes during this phase include upregulation of collagen genes, increased growth factor production, and early accumulation of new extracellular matrix components

doi:10.1038/labinvest.2017.59 29

noted that TB-500 may have a place in non-small cell lung cancer (NSCLC) therapy as it appears to suppress the proliferation of NSCLC cells by repressing Notch1 activation [10]

To achieve meaningful results, adaptive solutions must be systematically implemented, focusing on replicable, flexible, and cost-effective measures that generate co-benefits for health, the environment, and the economy (Orsetti et al., 2022)