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doi: 10.3389/fmolb.2025.1724944 Received 14 October 2025 Revised 18 November 2025 Accepted 30 November 2025 Published 18 December 2025 Volume 12 - 2025 Edited by Maria Barile, University of Bari Aldo Moro, Italy Reviewed by Anna Maria Giudetti, University of Salento, Italy Maria Tolomeo, National Research Council (CNR), Italy Updates Copyright 2025 Schrder, Jalilvand, Kahl, Kaiser and Liebau

S., Ye L., Dinkova-Kostova A

Overlapping conditions and diagnosis: Many other conditions have mast cell activation as a component, including idiopathic abdominal pain, GERD (heartburn), chronic urticaria, fibromyalgia, atypical drug and insect bite reactions, allergies, chronic sinusitis, pharyngitis and vocal tension, dermatographism, chronic headaches, interstitial cystitis, and atrial fibrillation.[ref] Additionally, some researchers point out the growing evidence of mast cell involvement in several different autoimmune diseases, including MS, type 1 diabetes, and rheumatoid arthritis.[ref] Lets dig into some of these in more depth, exploring how they relate to mast cell activation

Treatment for vitamin B12 deficiency is often with injections