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Information about previous treatments, including any history of similar reactions, is also valuable

Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature

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This metabolic symbiosis exhibits biphasic regulation: LNCaP cells upregulate Gln catabolic pathways (e.g., GLS1-dependent glutaminolysis), while CAFs activate extracellular matrix (ECM) remodeling pathways