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mucuso to reduce AchE activity, which is responsible for the degradation of acetylcholine, suggests increased cholinergic neurotransmission in the prefrontal cortex and hippocampus

While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose

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in severe cases of late CTS when numbness is constant and patients may not still be waking from sleep, injection of cortisone is not a useful test