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Platelet hyperactivity and infertility Platelets are essential for hemostasis, and abnormalities in their activation or hyperaggregability may play a role in the pathophysiology of conditions, including miscarriage and thrombosis with no known cause

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In practice, the challenge is rarely just "can GSH react?"it is whether the conjugation route will give the desired attachment site, manageable impurity profile, acceptable stability, and data that clearly distinguish the target product from free glutathione, oxidized material, and positional isomers

Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors, except for those published previously and approved by respective ethic committees