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1992 Nov;13(5):52732

In homozygotes, microglial and astrocyte activation appeared at 12 months, neuronal loss in the hippocampus and entorhinal cortex at 24 months, and synaptic loss at 8 months

doi: 10.1152/ajplegacy.1961.201.1.175

Alcohol Consumption: Excessive intake of alcohol prioritises its metabolism over uric acid due to the presence of ethanol, inhibiting the excretion of uric acid by the kidneys