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doi:10.1371/journal.pone.0000322 Sipiczki, M

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Joint cartilage has limited blood supply, and enhanced vascularity in the surrounding synovium and subchondral bone can improve nutrient delivery to damaged joint structures Anti-inflammatory modulation: BPC-157 modulates the nitric oxide system and reduces pro-inflammatory cytokines that drive arthritis progression Growth factor stimulation: The peptide upregulates vascular endothelial growth factor (VEGF) and growth hormone receptors, creating a more favorable environment for tissue repair Connective tissue healing: Research on tendons and ligaments demonstrates BPC-157's ability to accelerate healing in collagen-rich connective tissues, which are integral to joint structure Pain reduction: Through its anti-inflammatory and healing effects, BPC-157 may reduce joint pain at the source rather than simply masking it For detailed information on how BPC-157 supports tendon repair specifically, see our guide on peptides for tendon repair