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Patients with severe neurological complications from SARS-CoV-2 infection have an increased CSF Q-albumin ratio indicating BBB disruption, coupled with elevated CSF proteins, such as IL-8, which are associated with BBB disruption 65

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Notably, normal rats exhibited a superior sagittal sinus pressure of 24 to 27 mmHg and superior mesenteric pressure and portal pressure of 35 mmHg similar to that of the inferior vena cava, though with values at least 1 mmHg higher in the portal vein