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thaliana , six isoforms of MDHAR are present among which two are peroxisomal, two are cytosolic and one is dually targeted chloroplastic/mitochondrial isoform (Lisenbee et al., 2005) (Table 2)

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To assess the clinical effectiveness of the intervention, the number needed to treat (NNT), an absolute measure of effectiveness, was calculated as the inverse of absolute risk reduction (ARR) as an estimate of the overall clinical impact (NNT = 1/ARR), considering the median of weight reduction in the studied population (2.45 kg) as optimal

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