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AUC, area under the berberine plasma concentration-time curve

Furthermore, treatment of LNCaP prostate cancer cells with this trace mineral was found to cause an induction of GSTP1, APC and CSR1 promoter demethylation (through a decrease in the protein levels of DNMT1), in addition to a reduction in HDAC activity, leading to increased acetylation together with decreased methylation levels of lysine 9 on histone H3, which promoted gene expression ( Reference Xiang, Zhao and Song 64 )

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