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An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

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While GLP-1 therapies work through incretin pathways, cagrilintide activates amylin receptors located in key metabolic control centers of the brain[2]

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Wang Y, Qi C, Feng F, Hu X, Zhao N, Zhao J, et al

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The authors categorized studies into three key current research hotspots including (1) the mechanism by which gut microbiota metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFA) or LPS, influence the progression of CHD, (2) microbiota-targeted therapy in CHD management and (3) dietary modification as a possible tool to decelerate the progression of CHD

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