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For example, Bifidobacterium bifidum [138], with its hypoxia tropism, has been used to covalently modify calcium phosphate/silica nanoparticles loaded with doxorubicin, constructing the DNPs@Bi system that can actively target chemotherapy drugs to the hypoxic core of tumors, achieving effective killing of solid tumors through the combination of chemotherapy and immunogenic cell death effects

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Once a patients Vitamin B12 levels normalize, we transition to a maintenance therapy approach, ensuring that the recurrence of deficiency is prevented