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Given the relative concentrations of different ROS, the battery of H 2 O 2 -metabolizing enzymes potentially linked to glutathione, and the marked changes in glutathione status when other H 2 O 2 -metabolizing enzymes such as catalase are down-regulated, the main focus of the following discussion concerns the enzymes that could be important in linking H 2 O 2 or related peroxides to GSH oxidation to GSSG