15 min pre-incubation, 24 h co-incubation with oligomeric A 40 ) protects primary human astrocytes against oligomeric A 40 -induced cytotoxicity, apoptosis, oxidative stress, neuroinflammation, and dysregulated metalloproteinase activity, while restoring antioxidant status and GSH levels [7]
There are eight GPx homologs (GPx-1-8)
In response to oxidative stress, NRF2 dissociates from KEAP1, translocates to the nucleus, and activates genes encoding antioxidant enzymes (e.g., superoxide dismutase SOD) and glutathione synthesis enzymes, reducing reactive oxygen species (ROS) and mitigating oxidative damage (21)
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