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For instance, in a study examining cadmium-induced neurotoxicity in rats, NAC prevented the associated cognitive impairments, restored AChE activity, and reduced lipid peroxidation in the hippocampus, cerebellum, and hypothalamus [121]

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(9) Rotondi and colleagues have determined that seronegative autoimmune thyroiditis is a less aggressive form of Hashimotos, but nonetheless, the person may still develop hypothyroidism and even progress to other autoimmune conditions, which may or may not have respective positive antibody blood markers (such as seronegative rheumatoid arthritis)

These bioenergetic deficits contribute to muscle and neuronal fatigue ( This scoping review aims to examine the role of oxidative stress and mitochondrial dysfunction in FM, with a focus on redox imbalance, neuroinflammation, and potential therapeutic interventions targeting these pathways