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10.1136/jnnp-2013-306110 J

Such reverse engineering approaches are well developed for characterizing the functionality of complex technological systems (e.g., microelectronic devices) and there has been recent interest in developing reverse engineering as a systems biology tool 25,26,27,28,29,30,31

Key emerging areas such as the induction of ferroptosis, the selective targeting of CSCs, and the modulation of the tumor immune microenvironment are often omitted or underdeveloped in existing literature