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SIPS is a phenomenon characterized by the irreversible cessation of the division of normal cells even in presence of nutritional and mitogenic factors 27

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Nucleoporin (NUP), a constituent of the nuclear pore complex, has been found to be associated with HD pathology in HD mouse models and postmortem brains of HD patients [154]

Because it is non-pyrogenic, it does not contain fever-inducing substances (pyrogens), which is a baseline requirement for high-level research integrity