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In DCM, upregulation of the copper importer SLC31A1 makes patients exceptionally sensitive to chelators, whereby a standard dose can precipitate severe deficiency [240]

however, oxidative stress, which is a normal process and byproduct of brain functioning, reduces this spare capacity, limiting the ability to meet heightened needs (see Supplementary Figure 2A)

The consumer at-home category that this article addresses is much newer, and the long-term safety data for repeated bi-weekly stamping at 0.5 millimeters in a non-clinical environment is still accumulating

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