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Moreover, the ability of squalene epoxidase to participate in cancer development and migration can be limited by combining allylamine and its derivatives with anticancer drugs to limit the metastasis of cancer cells [177, 178]

For instance, in the case of advanced/metastatic non-small cell lung cancer (NSCLC) with METex14, GEOMETRY mono-1, a multicenter, open-label, multicohort phase 2 trial, demonstrated that capmatinib was highly effective against tumors in patients with advanced or metastatic NSCLC at stages IIIB and IV, particularly those with METex14 or MET amplification, especially in settings without prior treatment [27]

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Using the bioinformatics platform Starbase, multiple potential binding sites between YTHDF1 and SLC7A5were identified (Fig