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However, asynchrony between oocytes and spermatozoa, especially when aged oocytes are fertilized, will affect the rates of fertilization and embryo development, thus reliable methods are needed to control oocyte aging to benefit modern ART [28]

doi:10.2174/1381612826666200424180139 Park JM, Lee HJ, Sikiric P, Hahm KB

Some mechanistic research relies on non-disease-specific models or tumor cell lines, and the applicability of their conclusions in clinical settings of autoimmune diseases remains to be verified

Using a contaminated or unstable product introduces confounding variables and safety risks, making any research data unreliable