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In addition, avoiding direct comparison between the harms of traditional cigarettes and ENDS is recommended due to existing uncertainties, in particular those related to the high prevalence of dual or multiple product use, the variability of types/generations of ENDS and in their levels of nicotine content, and to a lack of rigourous and standardised comparative studies

Smoking adds more nicotine quickly, increasing the risk of serious side effects such as high blood pressure or heart problems

Brands find it a little tricky to protect them from crushing, sogging, and contaminations

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