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86 Notch signaling pathway Notch signaling, intimately involved in embryonic development and maintenance of multicellular organisms in adults, is activated by ligand-receptor interaction between adjacent cells, which leads to successive proteolytic cleavages and releases the notch intracellular domain (NICD)

This extended half-life keeps receptor activation constant throughout the week

The FDA recommends using a non-oral contraceptive method or a backup method for 4 weeks after starting tirzepatide and after each dose increase