Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome
Interestingly, transcriptome data showed that each of the 12 transcription factor families contained genes that could be induced by CHT, while inhibited by BSO or GSSG treatment
Moreover, their hydrophobic alkyl side chains enhance cell membrane affinity, facilitating interactions with intracellular signaling pathways 165
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