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Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development

This review synthesizes recent molecular insights into how Nrf2Keap1 signaling governs NLRP3 inflammasome activity, delineates the consequences of axis dysregulation for mitochondrial integrity and dopaminergic survival and critically appraises emerging pharmacological approaches aimed at restoring this balance to modify PD progression

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