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Steffen, Lees, and Booth [77] reported that the administration of either soluble TNF receptor-1 or the general inhibitor of TNF- production, pentoxifylline, attenuated losses in both body and skeletal muscle mass, and also reduced increases in ubiquitin proteasome pathway transcripts in an animal model of cardiac cachexia

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Lin SH, Komaki R, Liao Z, Wei C, Myles B, Guo X, Palmer M, Mohan R, Swisher SG , Hofstetter WL, Ajani JA, Cox JD