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Scrotal subcutaneous temperature is increased by scrotal insulation or whole-body heating, but not by scrotal neck insulation

Evidence remains uneven, as many studies infer vascular normalization from tumor growth delay or improved combination response, while fewer provide direct readouts of perfusion, vessel maturity, oxygenation, intratumoral drug distribution and the timing of the normalization window

It can help prevent adverse effects from drugs and environmental toxins

This dual role of modulating the protein synthesis-degradation balance and promoting myogenic differentiation highlights the therapeutic potential for caudatin in pathological states associated with muscle wasting (Figure 5A)