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As mentioned above, it activates nicotinic acetylcholine receptors (nAChRs), triggering dopamine release in the mesolimbic system, a mechanism similar to other addictive drugs like heroin and cocaine

It was reported that e-cigarettes and associated flavoring agents may produce harmful effects in stem cells and gingival fibroblasts by generating aldehydes/carbonyls from e-cigarette vapor, resulting in protein carbonylation and DNA damage, as well as cellular senescence 24

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