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Callaghan BC, Gao L, Li Y, Zhou X, Reynolds E, Banerjee M, et al

These mechanisms encompass hormonal signaling interference, metabolic pathway disruption, oxidative stress induction, and epigenetic modificationseach contributing to impaired spermatogenesis, compromised sperm function, and broader endocrine dysfunction

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It is designed to selectively disrupt the FOXO4-p53 interaction in senescent cells, enabling their targeted clearance while sparing healthy cells in preclinical models