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However, genetic or pharmacologic inhibition of RAS or its downstream signaling molecules (BRAF, MEK, and ERK) reversed the anticancer activity of erastin and RSL3 (Yang and Stockwell, 2008)

In the research context, Epithalon has been studied for effects on telomerase activity (an enzyme involved in maintaining telomeres), antioxidant defenses, and immune markers

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Mechanistically, SFN enhances the expression of cellular stress response proteins, such as heat shock proteins, and upregulates genes that protect cells against oxidative damage and inflammation