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Oral bioavailability will never approach injectable levels because the hepatic portal system forces every absorbed molecule through first-pass metabolism before systemic circulation

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25,26 ADAMTS-3 has been proposed as the major type II procollagen-processing enzyme, but it is also highly expressed in many Col1a1 -expressing tissues during mouse embryonic development and might be responsible for some of the type I procollagen N-endopeptidase activity, 26,27 and ADAMTS-14 has been shown to have type I procollagen I N-endopeptidase activity in vitro