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Some people feel slightly better within a few days, while others notice gradual improvement over one to two weeks

In practice a GP or nurse may administer off-licence by giving a sub-cutaneous (under the skin, SC) injection but it is important to remember that the GP makes their own decision and takes their own accountability and reliability if they go off-licence

Hypokalemia and thrombocytosis could occur upon conversion of severe megaloblastic anemia to normal erythropoiesis with methylcobalamin therapy

The studies tested various doses including 0.25 mg, 0.5 mg, and 1 mg daily via subcutaneous administration over periods ranging from single doses to 24 weeks of continuous therapy