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Most of the GSH (8085%) is stored in the cytosol, 1015% in the mitochondria (with an equal concentration between matrix and cytosol, thus requiring specific transport systems) and a small part in the endoplasmic reticulum (ER) (1, 6, 7)

The interaction between PINK1/Parkin and PGC-1 appears to co-regulate mitochondrial biogenesis and mitophagy, thereby maintaining mitochondrial homeostasis and mitochondrial quality control

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