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Numerical simulations Fluid flow was modeled in MATLAB (The MathWorks Inc., Natick, USA) and COMSOL (COMSOL Multiphysics 5.3a, COMSOL Multiphysics GmbH, Zrich, Switzerland) as described previously 25 COMSOL simulations were first used to calculate the fluidic resistance of the channel

Expert opinion Our analysis indicated that, under certain stress-related conditions, these precursors are cleaved to form immunologically active peptides that rapidly leave the nucleus and intracellular spaces, to send distress signals to the immune system, thereby acting as stress sensors

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