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Further studies are also needed in humans to determine whether APOE also influences L-carnitine metabolism following challenge and whether this impacts GBB and/or TMAO levels

While supplements are available, whole food sources are generally recommended as a first option

Int J Mol Sci 23:321335 Han Y-G, Qin X, Zhang T, Lei M, Sun F-Y, Sun J-J, Yuan W-F (2018) Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation

Mechanistically, bacterial antigens are captured by APCs in the skin, enhancing IL-1 signaling to polarize and train resident T cells into effector cytokine-producing cells