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Contemporary scientific investigations have validated the fact that traditional botanical drugs and their formulations derived from TCM and TM possess distinctive benefits for preventing and treating HACE by modulating mechanisms such as anti-hypoxia, hypoxic pulmonary hypertension reduction, angiogenesis and vasoconstriction inhibition, decreased blood-flow resistance, reduced cell permeability, inflammatory response alleviation, and anti-oxidative stress (Xie et al., 2022)

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