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Accumulated ROS under pathological conditions-such as inflammation, ischemia, or denervation-activate upstream kinases (ASK1, MKK3/6, MKK4/7), leading to p38 and JNK phosphorylation

IL-13 is overexpressed during allergic asthma attacks, augmenting canonical calcium mobilization pathways, enhancing calcium sensitization, and aggravating asthma presentation

doi: 10.1038/sj.onc.1208201 65 SturmIBosanquetAGHermannSGunerDDorkenBDanielPT

Medication-induced tinnitus often resolves within 1-2 weeks after stopping the medication, especially with drugs like high-dose aspirin, diuretics, other high blood pressure medications, and NSAIDs (e.g., ibuprofen, Aleve, etc.)