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While overall urinary GSH levels before and after the treatment did not show a significant difference (Supplemental Figure 16A), a significant decrease in urinary GSH levels was observed in seven patients who experienced more than a 50% reduction in urinary protein levels after steroid treatment (Supplemental Figure 16B)

GSH-T, total glutathione

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Therefore, clinical investigations, including research on piperine, are being conducted to clarify its potential advantages for children with autism [122]