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Funding This work was supported by the National Key R&D Program of China Scientific and Technological Innovation of Blue Granary (2018YFD0901504), the National Natural Science Foundation of China (31672630), the earmarked fund for CARS-50, Shandong Province Key Research and Development Program (2022LZGC004, 2021LZGC004), the Central Public-interest Scientific Institution Basal Research Fund (2020TD27)

Patients with glutathione synthetase deficiency typically present in the neonatal period with hemolytic anemia, metabolic acidosis and neurological impairment

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Increase dose slowly and not more often than once weekly