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BBB Disruption Caused by Oxidative Damage in the Brain The BBB is a highly selective and protective structure that separates circulating blood from the brains extracellular fluid, playing a crucial role in maintaining CNS homeostasis [141,142]

Morbidity and mortality in carriers of the cystic fibrosis mutation CFTR Phe508del in the general population

this also suggests a potential protective role of estrogens (Shimizu 2007)

In a recent preprint describing a prefusion-stabilized ectodomain of HSV-1 gB a similar flexibility of the central helix was seen, with two structures showing the helices either apart (open form) or in close proximity at the centre (closed form) 43