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In Vivo Subchronic Inhalation Testing The in vivo animal toxicology portion of Project MIX consisted of exposing male and female Sprague-Dawley rats, nose only, to either fresh air (sham) or diluted mainstream smoke from the Project MIX control and test cigarettes for 90 d, followed by a 42-d postexposure period, after which time the animals were sacrificed and histopathology studies were completed [18]

"The potential for irreparable damage to public health from the marketing of tobacco products with modified risk claims is well illustrated by the industry's years of deceptive advertising of 'light' and 'low-tar' cigarettes," the letter stated, as cited by the Associated Press

Future research with larger, representative samples will help clarify the relevance of these associations with nicotine exposure for non-daily smokers