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Given CHEs multidimensional burden, optimal diagnosis and treatment strategies to control the chronic signs and symptoms of disease are essential (Fig

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1,2 When the disorder affects only small, thinly myelinated or unmyelinated nerve fibers, it is referred to as small fiber neuropathy, which commonly presents as numbness and burning pain in the feet

rosea possesses antioxidant and mitochondrial-protective properties, effectively scavenging reactive oxygen species (ROS), stabilizing mitochondrial membrane potential, and augmenting adenosine triphosphate (ATP) synthesis, which collectively uphold neuronal bioenergetics during conditions of physiological stress (57)