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et al., 2018), but the mechanisms through which this injury occurs remain elusive

BMPs regulate NSC differentiation into astrocytes by acting through the phosphorylation of Smad proteins 1, 5, and 8, which combine with Smad4 in order to form a complex that translocates to the nucleus and regulates gene transcription (Itoh et al., 2000

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Differences in cell viability and rescue assays between the control and treatment groups were analyzed using a Williams' test, and the combination effects were evaluated using a two-way analysis of variance followed by a Tukey's test