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Lifestyle and dietary modifications: Weight loss (if appropriate) has the strongest evidence for improving reflux symptoms [2] Avoid eating within 2-3 hours of bedtime to reduce nighttime reflux Elevate the head of the bed by 68 inches using blocks or a wedge pillow Eat smaller, more frequent meals rather than large portions that increase gastric pressure Identify and avoid trigger foods such as caffeine, alcohol, chocolate, spicy foods, citrus, and high-fat meals Stop smoking , as tobacco use can worsen reflux symptoms If gastrointestinal symptoms are severe, your healthcare provider may consider slowing the tirzepatide dose titration schedule or adjusting the maintenance dose according to FDA prescribing information

Lung inflammation can be studied by testing the amount of bronchoalveolar lavage fluid (BALF), Muc5ac production, lung oxidative stress markers and airway hyperresponsiveness (AHR)

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