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Through its ability to activate NRF2, SFNs beneficial properties extend to mammalian cells and protect them from various external insults, including toxicants such as the endocrine disrupting chemical vinclozolin [33], nutrient deprivation [34, 35], and hypoxia [28, 36]

The study identifies how deficiency of the 2-oxoglutarate carrier (Slc25a11) can trigger harmful changes in retinal pigment epithelial (RPE) cellsaccelerating subretinal fibrosis, a major cause of vision loss in neovascular age-related macular degeneration (AMD)

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These patterns rarely have a single cause, which is why we assess rather than assume