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Evidence was grouped by peptide agent and clinical domain, including tendon and ligament healing, cartilage and osteoarthritis, bone remodeling and fracture repair, wound healing, and postoperative recovery

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Peptides derived from cytoskeletal proteins also tended to increase in abundance with age, including proteoforms of dematin actin-binding protein (DMTN), paralemmin-1 (PALM) and microtubule-associated proteins 1/2 (MAP1/2), which may represent degradation of full-length cytoskeletal proteins in later life, leading to cytoskeletal instability 36