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For example, the upregulation of the Nrf2 pathway by lipoic acid in cultured hepatocytes and in the liver of obese or diabetic rats prevented lipid overload-induced steatosis (35) and cell death (36)

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Likewise, acting through the NO-system, BPC 157 counteracted various opposite disturbances, i.e., prolonged miosis and prolonged mydriasis [111], consequences of hyperkalemia and hypokalemia [3], hypertension and hypotension [152], and bleeding and thrombosis [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168]

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